Pattern Recognition Receptor-Dependent Mechanisms of Acute Lung Injury
نویسندگان
چکیده
منابع مشابه
Pattern recognition receptor-dependent mechanisms of acute lung injury.
Acute lung injury (ALI) that clinically manifests as acute respiratory distress syndrome is caused by an uncontrolled systemic inflammatory response resulting from clinical events including sepsis, major surgery and trauma. Innate immunity activation plays a central role in the development of ALI. Innate immunity is activated through families of related pattern recognition receptors (PRRs), whi...
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Acute lung injury (ALI) induced by lipopolysaccharide (LPS) is a major cause of mortality among humans. ALI is characterized by microvascular protein leakage, neutrophil influx, and expression of proinflammatory mediators, followed by severe lung damage. LPS binding to its receptors is the crucial step in the causation of these multistep events. LPS binding and signaling involves CD14 and Toll-...
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ژورنال
عنوان ژورنال: Molecular Medicine
سال: 2009
ISSN: 1076-1551,1528-3658
DOI: 10.2119/molmed.2009.00097